Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in ...
The homeodomain factor Oct4 (Pou5f1) is a central component of transcriptional regulatory networks that maintain pluripotency in embryonic stem (ES) cells. Along with Sox2, Klf4, and Myc, Oct4 is one of the Yamanaka factors sufficient to induce the …